Delta Xi Nu Multicultural Sorority was established at Texas A&M University by five women who saw a need to promote friendship, diversity, and cultural awareness at the university and in the surrounding community. They envisioned an organization where women of all cultures would feel welcome, create lasting friendships, and educate and serve the community. The founding mothers are Rena Kharbat, Adrienne Magirl, Jetje Brewton, Lesliam Quiros, and Jaime Slaughter. Being African American, Dutch, Irish/Mexican, Palestinian, and Puerto Rican, the founding mothers wanted to show the world that it was their differences that had brought them together and made them stronger. All their hard work became a reality when Delta Xi Nu Sorority was finally recognized as a student organization on October 7, 1997.

In the Spring of 1998, Alpha Chapter held the first annual Unity Dinner. The dinner’s purpose is to bring students, faculty, and community members together and challenge them to think about culture and diversity in a way they never have before. Past keynote speakers include Kevin Powell from MTV’s Real World, former skinhead Frank Meink, and Lt. General Ricardo Sanchez. Over 200 people have attended the event in the past. Alpha Chapter’s philanthropy is AIDS awareness.

On December 7, 2001 Delta Xi Nu inducted the Beta Chapter of Tulane University located in New Orleans, LA.
Beta Chapter’s signature event is Shadows of Diversity. This event showcases the talents of the Tulane and New Orleans community. Everyone is invited to participate and share the uniqueness of their culture. The talent show is followed by a dinner consisting of foods from various cultures. Beta Chapter’s philanthropy is children’s education.

Gamma Chapter of Delta Xi Nu Sorority was inducted on April 17, 2004 at Colorado State University in Fort Collins, CO. These women chose Frindship Festival as their signature event. It’s purpose is to celebrate not only cultural differences, but also the similarities that all human beings share. Various student organizations set up booths around the campus plaza and entertainment groups perform throughout the day on a main stage. The women of Gamma Chapter hope to bring all CSU Greeks together and celebrate unity. Gamma Chapter’s philanthropy is domestic violence and drinking and driving.

Delta Colony of The University of Texas Pan American was inducted on April 16, 2005. The women are holding their first annual signature event, Dining with Culture, on April 21, 2006. The event consists of unique cultural entertainment while guests feast on a diverse cuisine. Delta Colony’s philanthropy is domestic violence against women.

On March 25, 2006, Epsilon Colony of Delta Xi Nu was inducted at Sam Houston State University. Their signature event is Destination Diversity. Guests can explore different cultures by visiting booths, listening to live music, and enjoying dance acts. The ladies' philanthropy is Children's Health Awareness.

Zeta Colony was inducted on April 29, 2006 at the University of Texas Arlington. Their signature event is Stomp out AIDS and philanthropy is Sexual Awareness.

In August of 2000, the Delta Xi Nu National Board was established in order to provide unity among all chapters and colonies, provide a central point for operations, and maintain the Sorority’s corporate affairs. In June of 2001, the National Alumni Association was founded to allow our sisters to continue the mission of promoting multiculturalism and to help our organization continue to grow.